Inflammatory Bowel Disease (IBD) Research Symposium

J7075

Educate local and regional investigators and specialty providers about IBD-related research being undertaken at Penn State College of Medicine and facilitate scientific collaborations relating to IBD among basic, translational and clinical researchers.

U.S.-based physicians and researchers in the field of gastroenterology, as well as pharmacists and other interested health care professionals, may all benefit from attendance.

The overall goal of our conference is to improve the care and management of patients with IBD through the promotion and enhancement of IBD-associated research work at our institution and throughout Pennsylvania and the Mid-Atlantic region. This will improve the care of patients with IBD by increasing health care providers’ knowledge of the emerging strategies for the treatment of IBD.

1. Describe IBD-related research resources, active projects and current opportunities for scientific collaboration at the Penn State College of Medicine.
2. Discuss cutting edge research related to function and role of the intestinal epithelial barrier in IBD.
3. Review current studies utilizing bioinformatics and artificial intelligence and their potential application to better understanding IBD.
4. Discuss recent clinical and translational research related to IBD and its application to patient care.

• 7:30 a.m. | Check-In / Continental Breakfast / Visit Exhibitors
• 8 a.m. | Opening Remarks
  Matthew Coates, MD, PhD
  Greg Yochum, PhD
  Biobank / GI Registry Introduction

  Objectives

  • Review current resources available to support digestive disease research, including projects that are specific to gastroenterology and/or require endoscopically derived biospecimens
  • Discuss current collaborations and describe how to access the resources above and initiate digestive disease related research at Penn State

Session 1: Immune Response; Moderator: Iryna Pinchuk, PhD

• 8:15 a.m. | Innate Immunity at Crossroads of Gut Inflammation and Resistance to Therapeutics in IBD
  Distinguished Presenter: Ronen Sumagin, Associate Professor of Pathology, Northwestern Univ

  Objectives

  • Outline neutrophil localization and trafficking mechanisms in inflamed intestines
  • Discuss potential mechanisms by which neutrophils may contribute to resistance to biologics in IBD
• 8:50 a.m. | Fibroblast-Mediated Microbial Sensing and Crosstalk with Macrophages in IBD Animal Model
  Marina Chulkina, PhD

  Objectives

  • Define microbial sensing pathways in fibroblast subsets from healthy and IBD intestinal tissue
  • Outline how fibroblast-intrinsic MyD88 signaling supports intestinal mucosal macrophage antimicrobial function via IL 6 and CCL2
• 9:15 a.m. | Targeting MyD88-JAK2 Signaling in Aberrantly Differentiated Mesenchymal Progenitors in Ulcerative Colitis
  Ronaldo Paolo P. Panganiban, MD

  Objectives

  • Describe how mesenchymal stromal cell (MSC) dysfunction and dysregulated MyD88–JAK2 signaling contribute to chronic inflammation in ulcerative colitis
  • Evaluate the therapeutic potential of microbiota- and mesenchymal-targeted combination strategies—such as MSC and fecal microbiota transplantation (FMT)—in improving outcomes in preclinical models of ulcerative colitis
• 9:40 a.m. | Break / Visit Exhibitors

Session 2: Epithelium; Moderator: Greg Yochum, PhD

• 9:55 a.m. | A High-Throughput Glycomics Platform for Personalized Prebiotic Development
  Seth Kabonick, PhD

  Objectives

  • Develop a glycomics platform to survey the vast array of complex sugars in the host diet and mucosa
  • Engineer prebiotics to leverage resident microbes as therapeutic tools for the treatment of IBD and other host diseases
• 10:20 a.m. | Hemp Extracts as an Emerging Therapeutic for IBD
  Wesley Raup-Konsavage, PhD

  Objectives

  • Differentiate between hemp/cannabis extracts and pure cannabinoids, and implications of the entourage effect for therapies
  • Discuss the potential of hemp extractions in IBD and the considerations and challenges translating the therapies into the clinic
• 10:45 a.m. | Intestinal Epithelial Tight Junction Regulation by Aryl Hydrocarbon Receptor is Critical for Gut Immune Homeostasis
  Priya Arumugam, PhD

  Objectives

  • Describe the components of barrier integrity beyond tight junctions and analyze the relationship between gut permeability and mucosal protection in maintaining gut homeostasis
  • Explain the function of the aryl hydrocarbon receptor (AhR) in regulating and maintaining the integrity of the intestinal epithelial barrier
• 11:10 a.m. | Break / Visit Exhibitors
• 11:20 a.m. | KEYNOTE
  Single-Cell Dissection of Region-Specific Phenotypes in Inflammatory Bowel Disease and Colorectal Precancer
  Ken Lau, PhD

  Objectives

  • Highlight human relevant profiling technologies for profiling healthy and diseased gut tissues
  • Discuss gut region specific biology and its implications on disease
• 12:15 p.m. | Lunch / Visit Exhibitors

  Industry-Sponsored Symposium
  Not for CME credit
  Promotional speaker program sponsored by Janssen Biotech, Inc., a Johnson & Johnson company
  Optional session available in Weitzel Room

Session 3: Clinical Research; Moderator: Matthew Coates, MD, PhD

• 1:30 p.m. | A Low Sulfur Diet for Quiescent Crohn’s Disease
  Guest Presenter: Allen Lee, MD, MS

  Objectives

  • Outline the potential mechanisms leading to persistent symptoms in quiescent Crohn’s disease
  • Identify novel therapies for quiescent Crohn’s disease patients with persistent symptoms
• 2:15 p.m. | Break / Visit Exhibitors

Session 4: Patient Care/ Management; Moderator: Matthew Coates, MD, PhD

• 2:30 p.m. | Can We See the Writing on the Wall? The Intersection of Advanced Therapies and Surgery in Patients with IBD
  Audrey Kulaylat, MD, MS

  Objectives

  • Analyze patterns of biologic therapy use in patients prior to surgical intervention
  • Evaluate the impact of preoperative biologic switching on disease outcomes
  • Identify current challenges in predicting therapeutic response and explore emerging strategies for improvement
• 2:50 p.m. | Nutritional Considerations in Inflammatory Bowel Disease
  Heather Tressler, RDN

  Objectives

  • Review common macro- and micronutrient deficiencies in IBD
  • Discuss strategies to manage nutrient deficiencies in individuals with IBD
• 3:10 p.m. | Empiric Antibiotic Use with Rescue Infliximab Does Not Improve Outcomes in Acute Severe Ulcerative Colitis: A Retrospective Cohort Study
  Kofi Clarke, MD, FACP, FRCP (Lond.), AGAF

  Objectives

  • Review clinical presentations of Acute Severe Ulcerative Colitis (ACUS)
  • Explain effective management strategies for ACUS
• 3:30 p.m. | Cannabis and IBD
  Matthew Coates, MD, PhD

  Objectives

  • Review and discuss recent research related to the impact of cannabis and its derivatives in the setting of inflammatory bowel disease
  • Describe potential applications of these findings, and discuss future study opportunities related to this topic
• 3:50 p.m. | Closing remarks
• 4 p.m. | Adjourn

Kofi Clarke, MD, FACP, FRCP
Professor, Department of Medicine
Chief, Division of Gastroenterology and Hepatology
Penn State College of Medicine
Penn State Milton S. Hershey Medical Center

Matthew Coates, MD, PhD
Associate Professor and Margot E. Walrath Career Development Professor in Gastroenterology
Department of Medicine
Director of Research, Division of Gastroenterology and Hepatology Associate Professor of Pharmacology
Penn State College of Medicine
Penn State Milton S. Hershey Medical Center

Prashant Nighot, MVSc, PhD
Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Penn State College of Medicine
Penn State Milton S. Hershey Medical Center

Gregory Yochum, PhD
Associate Professor of Biochemistry and Molecular Biology and Surgery Mechanisms of Carcinogenesis
Penn State Cancer Institute
Penn State College of Medicine
Penn State Milton S. Hershey Medical Center

Ken Lau, PhD
Professor of Cell and Developmental Biology and Surgery
Vanderbilt University

Allen Lee, MD, MS
Assistant Professor of Medicine
University of Michigan

Ronen Sumagin, PhD
Associate Professor of Pathology
Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center
Northwestern University

Our visiting presenters are Funded in partnership with the William E. Schiller Memorial Lectureship, in memory of William E Schiller, former Chairman of Hershey Foods

AMA

Penn State College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Penn State College of Medicine designates this live activity for a maximum of 6.5 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses Using AMA Credit

Nurses will receive a certificate from Penn State College of Medicine verifying their participation in up to 6.5 hours of approved continuing medical education. Continuing education activities which are approved by accredited institutions of higher education and that are relevant to patient care or professional nursing meet the requirements of mandatory continuing education for registered nurses in Pennsylvania, as required by the Pennsylvania State Board of Nursing. The Board of Nursing recommends that nurses retain their certificates for a period of at least five years. Additional information is available through the State Board of Nursing.

Accreditation Council for Pharmacy Education (ACPE)

Penn State Health Milton S. Hershey Medical Center is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

This knowledge-based activity has been assigned the Universal Activity Number of 0322-0000-25-017-L01-P. It has been approved for 6 contact hours (0.6 CEU) of continuing pharmacy education credit in states that recognize ACPE providers. The attendee list will be uploaded into CPE Monitor approximately two weeks after completion of the program.

There is no fee, but registration is required.

Accommodations are the responsibility of the program participant. A list of Hershey area lodging is available upon request or online at ce.med.psu.edu/lodging.

Join us in Hershey

Hershey is conveniently located in central Pennsylvania, just 90 minutes from Baltimore and Philadelphia, two hours from Washington, D.C., and three hours from New York City.

• Harrisburg-Area Attractions
• Hershey Attractions
• Tanger Outlets in Hershey
• Historic Gettysburg
• Pennsylvania Dutch and Amish Country

A completed evaluation is required in order to receive a certificate for attending this activity. Please complete and submit the evaluation within the specified time frame.

The University reserves the right to cancel or postpone any course or activity because of insufficient enrollment or other unforeseen circumstances. If a program is canceled or postponed, the University will refund any program registration fees paid but cannot be held responsible for any related costs, charges or expenses, including cancellation/change charges assessed by airlines or travel agencies.

Program registrants who are experiencing illness or have been exposed to anyone who is ill should contact the Continuing Education office before attending any in-person activities.

Content and speakers for all programs are subject to change. Registrants will be notified of any significant updates.

On-campus educational activities provided by Penn State College of Medicine Continuing Education are required to follow healthcare facility guidelines. Off-campus events provided by Penn State College of Medicine Continuing Education follow the COVID-19 requirements of that venue. We ask that all participants respect that some attendees may still choose to wear masks for activities. Check the venue website for the latest requirements and recommendations. Please do not attend this activity if you have symptoms or have been exposed to someone with COVID-19. By attending the activity, you attest that you do not have any symptoms suggestive of COVID-19, which may include fever, cough, shortness of breath, sore throat, loss of taste, loss of smell or any other sign of illness.

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